Biggest challenge: Run defense.

There’s admittedly some recency bias here, but how could there not be? The Bills exploded out to a 3-0 start until the Ravens literally ran the ball down their throats on Sunday night. It wasn’t like Buffalo didn’t know what was coming. It’s also not like the Bills had been bad against the run before Week 4 arrived (they hadn’t). It’s just that Buffalo hadn’t faced a rushing attack like Baltimore’s in those first three wins, and its weaknesses showed immediately as it eventually gave up 271 yards on the ground. As soon as Derrick Henry raced off to an 87-yard touchdown run on Baltimore’s first offensive play, you knew it was going to be a long night for Buffalo. 

The Bills don’t field the biggest defense around, and they’re missing their two best linebackers (Matt Milano and Terrel Bernard). Those factors were going to bite this team at some point, and it just happened to come in a 35-10 beatdown in front of a nationally televised audience. Buffalo will certainly look better against the run in the coming weeks, especially since its next five games will be played against teams that rank in the bottom half of the league in rushing. But this is something to remember. It was that bad against Baltimore.