Here’s how the top-flight table looks before Saturday’s 3pm action gets underway in just over half-an-hour.
Two changes for both West Ham and Everton as the two sides meet, with Mohammed Kudus and Edson Alvarez unavailable due to suspension.
West Ham XI: Fabianski, Wan-Bissaka, Todibo, Kilman, Emerson, Soucek, Rodriguez, Bowen, Paqueta, Summerville, Antonio
Subs: Foderingham, Cresswell, Soler, Coufal, Mavropanos, Guilherme, Ings, Irving, Scarles.
For Everton, Jarrad Branthwaite makes his second start of the campaign but talisman Dwight McNeil misses out through injury.
Everton XI: Pickford, Young, Tarkowski, Branthwaite, Mykolenko, Gueye, Mangala, Lindstrom, Doucoure, Ndiaye, Calvert-Lewin.
Subs: Virginia, Begovic, Patterson, Keane, Harrison, Beto, O’Brien, Armstrong, Bates.
Mario Lemina returns for Wolves to captain the hosts against Southampton, who are unchanged from the win over Everton.
Wolves XI: Sa, Bueno, Dawson, Toti, Semedo, J Gomes, Lemina, Sarabia, Ait-Nouri, Cunha, Strand Larsen.
Subs: Doherty, Andre, R Gomes, Doyle, Forbs, Bellegarde, Guedes, Pond, Bentley.
Southampton XI: Ramsdale, Walker-Peters, Harwood-Bellis, Bednarek, Manning, Stephens, Downes, Lallana, Fernandes, Armstrong, Archer.
Subs: Bree, Aribo, Dibling, Brereton-Diaz, Amo-Ameyaw, Sugawara, Onuachu, Ugochukwu, McCarthy.
Elsewhere, Crystal Palace are without the suspended Will Hughes and the injured Eddie Nketiah for their crunch clash against Fulham.
Crystal Palace XI: Henderson, Chalobah, Lacroix, Guehi, Munoz, Kamada, Clyne, Mitchell, Devenny, Sarr, Mateta.
Subs: Turner, Matthews, Schlupp, Ward, Richards, Doucoure, Kporha, Marsh, Agbinone.
Fulham XI: Leno, Tete, Andersen, Bassey, Robinson, Pereira, Berge, Nelson, Smith Rowe, Iwobi, Jimenez.
Subs: Benda, Reed, Wilson, Rodrigo Muniz, Cairney, Traore, Castagne, Sessegnon, Diop.
And finally, Chelsea loanee goalkeeper Kepa Arrizabalaga has returned from injury to start for Bournemouth away at Brentford.
Brentford XI: Flekken, Collins, Pinnock, Van den Berg, Norgaard, Janelt, Jensen, Damsgaard, Mbeumo, Lewis-Potter, Wissa.
Subs: Schade, Carvalho, Mee, Yarmoliuk, Meghoma, Konak, Roerslev, Maghoma, Valdimarsson.
Bournemouth XI: Kepa, Smith, Zabarnyi, Senesi, Kerkez, Cook, Christie, Semenyo, Kluivert, Adams, Evanilson.
Subs: Huijsen, Brooks, Tavernier, Araujo, Hill, Unal, Billing, Aarons, Travers.