Samuel broke out in a big way last week, catching seven of nine targets for 96 yards and a touchdown, while running for an additional 25 yards. In total, he finished with 25.1 fantasy points, which was more than he’d managed in his previous five games combined. Jennings was held in check for the second straight week, though. Both are in play against the Lions, who have allowed the second-most yards and fourth-most fantasy PPG to receivers. They have given up the most yards to slot receivers, and Jennings runs a third of his routes from the slot. Detroit uses man coverage at the highest rate in the league, and Jennings has a team-high 139.9 passer rating when targeted against man. Both Niners wideouts bring enticing upside in a game where the 49ers could be chasing points.