The 2025 NFL playoff bracket begins with the 2025 Wild Card Weekend NFL schedule, as six games will take place from Saturday to Monday. Baltimore closed the regular season on a four-game winning streak, with all four of those victories coming by at least 17 points. The Ravens will host division-rival Pittsburgh on Saturday as 9.5-point favorites in the Wild Card Weekend NFL odds from the SportsLine Consensus. Baltimore cruised to a 34-17 win in Week 16, but Pittsburgh notched an 18-16 win in Week 11.
That is the only game between division-rivals this weekend, but there are other NFL matchups like the Eagles (-4.5) vs. Packers and Rams (+1.5) vs. Vikings. Which games should you target when you build your Wild Card Weekend NFL parlay picks? Before you make any Wild Card Weekend NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine’s proven computer model.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters the 2025 NFL playoffs on a 31-14 betting hot streak on top-rated NFL picks this year — a stunning 69% success rate. Longer term, it is on a 211-142 roll on top-rated NFL picks that dates back to the 2017 season and a 65-35 roll on top-rated NFL picks since Week 7 of 2022.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone following at sportsbooks and on betting apps could have seen strong returns.
Now, the model has scoured the Wild Card Weekend NFL odds and locked in five confident NFL best bets. If you successfully parlay its sports betting picks, you’d be looking at a massive payout of around 25-1. You can only see the model’s Wild Card Weekend NFL picks at SportsLine.
After simulating every game 10,000 times, the model is high on the Buffalo Bills (-8.5, 47) to cover against the Denver Broncos. Denver won five of its final seven games to close the regular season, and it has covered the spread in six of its last eight games. However, this has proven to be a difficult matchup in recent years, with the Bills covering the spread in seven of the last eight head-to-head meetings.
Buffalo is riding an eight-game home winning streak and has covered in eight of its last 12 games overall this season. The Bills are averaging nearly 32 points per game, powered by star quarterback Josh Allen. Denver is averaging 24 points with rookie quarterback Bo Nix at the helm, and that experience gap is one reason why the model has the Bills covering the spread in well over 50% of simulations. See which other NFL parlay picks to make here.
The model also jumped on four other NFL matchups where it says the line is way off, including a pair of underdogs that nearly win outright. You can only see the model’s Wild Card Weekend NFL best bets and NFL parlay at SportsLine.
What are the model’s top Wild Card Weekend NFL picks, and which NFL matchups should you target for an epic 25-1 payout? Visit SportsLine now to see the Wild Card Weekend NFL best bets from a model on an 211-142 run on top-rated picks, and find out.
