The regular season has been extended to 18 weeks with each team now playing 17 games. All 18 weeks of the regular season will see a ton of action, with NFL lines and spreads typically coming out for the next week right after the previous week’s games have ended.

Throughout the regular season, NFL game odds and lines can shift dramatically based on the latest NFL lineups, recent performances, injuries, and player movement. Most NFL betting lines for an upcoming week of games are released late on Sunday night. 

Each game will feature a moneyline as well. The moneyline is the most straightforward NFL bet. All players need to do is bet on who will win the game outright. The margin of victory does not matter, only the outcome.

Oddsmakers create lines that will encourage an equal amount of betting action on both sides, using injuries, home-field advantage and the weather to help determine and set these lines.

Oddsmakers use point spreads to balance two uneven teams. In virtually every game, there will be a favorite (-) and an underdog (+). The number after the minus sign for a favorite indicates how much you must bet to win $100. The number after the plus sign indicates how much you would win on a successful $100 wager.

If you don’t want to bet on the outcome or spread of an NFL game, you can bet on the over/under. Operators will set a total projected number of points expected to be scored during a game, and it’s up to you to decide whether to bet that there will be more or fewer total points scored. 

One of the best pieces of advice we can offer is to shop NFL odds among various sportsbooks for the best NFL game lines. You can often find dramatically different point spreads, NFL moneylines and totals. 

Keeping track of which betting sites offer the best NFL betting lines and following them throughout the week can be extremely advantageous. Be sure to frequently check in on the NFL game lines here to see how they are moving throughout the week, especially after injury reports are released.